Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 27, 2020
Previous Article Next Article

Optimization of ring-opening metathesis polymerization (ROMP) under physiologically relevant conditions

Author affiliations

Abstract

Ring opening metathesis polymerization (ROMP) is widely considered an excellent living polymerization technique that proceeds rapidly under ambient conditions and is highly functional group tolerant when performed in organic solvents. However, achieving the same level of success in aqueous media has proved to be challenging, often requiring an organic co-solvent or a very low pH to obtain fast initiation and high monomer conversion. The ability to efficiently conduct ROMP under neutral pH aqueous conditions would mark an important step towards utilizing aqueous ROMP with acid-sensitive functional groups or within a biological setting. Herein we describe our efforts to optimize ROMP in an aqueous environment under neutral pH conditions. Specifically, we found that the presence of excess chloride in solution as well as relatively small changes in pH near physiological conditions have a profound effect on molecular weight control, polymerization rate and overall monomer conversion. Additionally, we have applied our optimized conditions to polymerize a broad scope of water-soluble monomers and used this methodology to produce nanostructures via ring opening metathesis polymerization induced self-assembly (ROMPISA) under neutral pH aqueous conditions.

Graphical abstract: Optimization of ring-opening metathesis polymerization (ROMP) under physiologically relevant conditions

Back to tab navigation

Supplementary files

Article information


Submitted
15 May 2020
Accepted
17 Jun 2020
First published
18 Jun 2020

Polym. Chem., 2020,11, 4492-4499
Article type
Paper

Optimization of ring-opening metathesis polymerization (ROMP) under physiologically relevant conditions

D. C. Church, L. Takiguchi and J. K. Pokorski, Polym. Chem., 2020, 11, 4492
DOI: 10.1039/D0PY00716A

Social activity

Search articles by author

Spotlight

Advertisements