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Issue 38, 2020
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Two- and three-photon excitable quaternized imidazo[1,2-a]pyridines as mitochondrial imaging and potent cancer therapy agents

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Abstract

We have synthesized a series of quaternized imidazo[1,2-a]pyridines in three steps from commercially available reagents. These compounds exhibit blue fluorescence emission at around 425 nm with good quantum yields. In addition, one specific compound was found to work as not only a two- and three-photon excitable mitochondria imaging agent, but also a therapeutic agent upon continuous irradiation conditions.

Graphical abstract: Two- and three-photon excitable quaternized imidazo[1,2-a]pyridines as mitochondrial imaging and potent cancer therapy agents

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Article information


Submitted
31 Jul 2020
Accepted
07 Sep 2020
First published
08 Sep 2020

Org. Biomol. Chem., 2020,18, 7571-7576
Article type
Paper

Two- and three-photon excitable quaternized imidazo[1,2-a]pyridines as mitochondrial imaging and potent cancer therapy agents

E. Hase, H. Takanari, K. Hoshi, M. Okamoto, A. Tabata, H. Nagamune, T. Minamikawa, T. Yasui, Y. Yoshida, K. Minagawa, Y. Kawamura, Y. Imada and F. Yagishita, Org. Biomol. Chem., 2020, 18, 7571
DOI: 10.1039/D0OB01585G

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