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Issue 32, 2020
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Biodegradable microneedle patch for transdermal gene delivery

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Abstract

The skin houses a developed vascular and lymphatic network with a significant population of immune cells. Because of the properties of the skin, nucleic acid delivery through the tissue has the potential to treat a range of pathologies, including genetic skin conditions, hyperproliferative diseases, cutaneous cancers, wounds, and infections. This work presents a gelatin methacryloyl (GelMA) microneedle (MN)-based platform for local and controlled transdermal delivery of plasmid DNA (pDNA) with high transfection efficiency both in vitro and in vivo. Intracellular delivery of the nucleic acid cargo is enabled by poly(β-amino ester) (PBAE) nanoparticles (NPs). After being embedded in the GelMA MNs, sustained release of DNA-encapsulated PBAE NPs is achieved and the release profiles can be controlled by adjusting the degree of crosslinking of the GelMA hydrogel. These results highlight the advantages and potential of using PBAE/DNA NP-embedded GelMA MN patches (MN/PBAE/DNA) for successful transdermal delivery of pDNA for tissue regeneration and cancer therapy.

Graphical abstract: Biodegradable microneedle patch for transdermal gene delivery

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Supplementary files

Article information


Submitted
07 Apr 2020
Accepted
23 Jul 2020
First published
12 Aug 2020

Nanoscale, 2020,12, 16724-16729
Article type
Communication

Biodegradable microneedle patch for transdermal gene delivery

M. Qu, H. Kim, X. Zhou, C. Wang, X. Jiang, J. Zhu, Y. Xue, P. Tebon, S. A. Sarabi, S. Ahadian, M. R. Dokmeci, S. Zhu, Z. Gu, W. Sun and A. Khademhosseini, Nanoscale, 2020, 12, 16724
DOI: 10.1039/D0NR02759F

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