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Issue 2, 2020
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Interference of pH buffer with Pb2+-peripheral domain interactions: obstacle or opportunity?

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Abstract

Pb2+ is a xenobiotic metal ion that competes for Ca2+-binding sites in proteins. Using the peripheral Ca2+-sensing domains of Syt1, we show that the chelating pH buffer Bis–Tris enables identification and functional characterization of high-affinity Pb2+ sites that are likely to be targeted by bioavailable Pb2+.

Graphical abstract: Interference of pH buffer with Pb2+-peripheral domain interactions: obstacle or opportunity?

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Supplementary files

Article information


Submitted
02 Jan 2020
Accepted
05 Feb 2020
First published
05 Feb 2020

Metallomics, 2020,12, 164-172
Article type
Communication

Interference of pH buffer with Pb2+-peripheral domain interactions: obstacle or opportunity?

S. Katti and T. I. Igumenova, Metallomics, 2020, 12, 164
DOI: 10.1039/D0MT00002G

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