Hierarchical binding of copperII to N-truncated Aβ4–16 peptide

Xiangyu Teng; Ewelina Stefaniak; Paul Girvan; Radosław Kotuniak; Dawid Płonka; Wojciech Bal; Liming Ying

doi:10.1039/C9MT00299E

Hierarchical binding of copper^II to N-truncated Aβ_4–16 peptide†

Xiangyu Teng,

‡^a Ewelina Stefaniak,

‡^b Paul Girvan,

^a Radosław Kotuniak,

^b Dawid Płonka,

^b Wojciech Bal

*^b and Liming Ying

*^c

Author affiliations

* Corresponding authors

^a Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, London W12 0BZ, UK

^b Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland
E-mail: wbal@ibb.waw.pl

^c National Heart and Lung Institute, Imperial College London, Molecular Sciences Research Hub, White City Campus, London W12 0BZ, UK
E-mail: l.ying@imperial.ac.uk

Abstract

N-Truncated Aβ_4–42 displays a high binding affinity with Cu^II. A mechanistic scheme of the interactions between Aβ_4–42 and Cu^II has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ_4–42 during neurotransmission.

Metallomics

Hierarchical binding of copper^II to N-truncated Aβ_4–16 peptide†

Abstract

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Metallomics

Hierarchical binding of copperII to N-truncated Aβ4–16 peptide†

Abstract

Supplementary files

Article information

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Hierarchical binding of copper^II to N-truncated Aβ_4–16 peptide†