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Issue 12, 2020
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T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles

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Abstract

T cell-based cancer immunotherapy has achieved great success in the clinic; however, only a small fraction of patients respond to this therapy. Strategies to specifically and safely augment anticancer activity through controlled delivery of T cell supporting factors or drugs for combination therapy remain of high interest. Here, we devised a T cell force-responsive system for selective delivery of anticancer drugs using a mesoporous silica microparticle capped with a DNA force sensor. Upon T cell receptor (TCR) triggering, T cells exerted synaptic forces, a unique biophysical stimulus, to rupture the force-sensitive DNA gatekeepers on the mesopores leading to rapid drug release. Our results demonstrated that this cellular force-responsive system specifically released anticancer drugs in a T cell force-dependent manner and significantly enhanced cancer cell killing in vitro and in vivo. This work opens a new horizon toward designing next-generation drug delivery systems in response to signaling-specific cellular forces.

Graphical abstract: T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles

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Supplementary files

Article information


Submitted
09 Aug 2020
Accepted
21 Oct 2020
First published
22 Oct 2020

Mater. Horiz., 2020,7, 3196-3200
Article type
Communication

T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles

K. Lei and L. Tang, Mater. Horiz., 2020, 7, 3196
DOI: 10.1039/D0MH01285H

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