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Issue 12, 2020
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Acylation/cyclization of 1,6-dienes with ethers under catalyst- and base-free conditions

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Abstract

A concise and eco-friendly acylation/cyclization of 1,6-dienes with linear ethers under catalyst- and base-free conditions has been developed. tert-Butyl hydroperoxide (TBHP)-promoted tandem cleavage of C(sp3)–H and C(sp3)–O bonds of linear ethers is the key in this process, which provides a straightforward and efficient method to realize acylation reaction. The significant advantages of this method include catalyst- and base-free, mild reaction conditions, high scalability, operational simplicity, ease of scale-up, dual roles of ethers and controllable synthesis.

Graphical abstract: Acylation/cyclization of 1,6-dienes with ethers under catalyst- and base-free conditions

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Supplementary files

Article information


Submitted
10 Mar 2020
Accepted
22 May 2020
First published
25 May 2020

Green Chem., 2020,22, 3952-3955
Article type
Paper

Acylation/cyclization of 1,6-dienes with ethers under catalyst- and base-free conditions

X. Huang, F. Qin, Y. Liu, S. Wu, Q. Li and W. Wei, Green Chem., 2020, 22, 3952
DOI: 10.1039/D0GC00865F

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