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Issue 4, 2020
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The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials

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Abstract

Background: Previous studies did not draw a consistent conclusion about the effects of vitamin K combined with vitamin D on human skeletal quality. Method and findings: A comprehensive search on Web of Science, PubMed, Embase and the Cochrane Library (from 1950 to February 2020) and bibliographies of relevant articles was undertaken, with the meta-analysis of eight randomized controlled trials (RCTs) including a total of 971 subjects. Vitamin K combined with vitamin D significantly increased the total bone mineral density (BMD): the pooled effect size was 0.316 [95% CI (confidence interval), 0.031 to 0.601]. A significant decrease in undercarboxylated osteocalcin (−0.945, −1.113 to −0.778) can be observed with the combination of vitamin K and D. Simultaneously, subgroup analysis showed that K2 or vitamin K (not specified) supplement was less than 500 μg d−1, which when combined with vitamin D can significantly increase the total BMD compared with the control group fed a normal diet or the group with no treatment (0.479, 0.101 to 0.858 and 0.570, 0.196 to 0.945). Conclusions: The combination of vitamin K and D can significantly increase the total BMD and significantly decrease undercarboxylated osteocalcin, and a more favorable effect is expected when vitamin K2 is used.

Graphical abstract: The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials

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Supplementary files

Article information


Submitted
25 Dec 2019
Accepted
27 Feb 2020
First published
09 Mar 2020

Food Funct., 2020,11, 3280-3297
Article type
Paper

The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials

X. Kuang, C. Liu, X. Guo, K. Li, Q. Deng and D. Li, Food Funct., 2020, 11, 3280
DOI: 10.1039/C9FO03063H

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