Jump to main content
Jump to site search

Issue 38, 2020
Previous Article Next Article

Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2′-bipyridine)2(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution

Author affiliations

Abstract

A new class of light-activated ruthenium(II) complex was designed as a potential blocker of biological functioning, especially for targeting redox reactions within mitochondria under light activation. Based on our concepts the complex [Ru(bipy)2(1-hydroxyanthra-9,10 quinone)]Cl (RU1) was prepared and studied to understand the preliminary reaction mechanisms and its excited state behaviour through a series of stability tests, electrochemistry, UV–Visible kinetics and femtosecond transient absorption spectroscopy experiments. Under white light in the presence of H2O2 two different reactions (fast and slow) appear to take place. The complex loses the quinone-based ligand and a resulting Ru(III) or Ru(V) species is produced. The complex RU1 shows potential to consume H2O2 from the one carbon metabolism in mitochondria, and hence may cut the energy cycle pathway of tumor cells.

Graphical abstract: Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2′-bipyridine)2(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution

Back to tab navigation

Supplementary files

Article information


Submitted
02 Jul 2020
Accepted
17 Aug 2020
First published
19 Aug 2020

This article is Open Access

Dalton Trans., 2020,49, 13243-13252
Article type
Paper

Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2′-bipyridine)2(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution

L. Zeng, D. Sirbu, P. G. Waddell, N. V. Tkachenko, M. R. Probert and A. C. Benniston, Dalton Trans., 2020, 49, 13243
DOI: 10.1039/D0DT02339F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements