Issue 35, 2020
From the journal:

Dalton Transactions

Avobenzone incorporation in a diverse range of Ru(ii) scaffolds produces potent potential antineoplastic agents†

Raphael T. Ryan, ORCID logo a   Dmytro Havrylyuk,a   Kimberly C. Stevens,a   L. Henry Moore,b   Doo Young Kim, ORCID logo a   Jessica S. Blackburn,b   David K. Heidary,*a   John P. Selegue*a  and  Edith C. Glazer ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Kentucky, 505 Rose Street, Lexington, KY 40506, USA
E-mail: ec.glazer@uky.edu

b Department of Molecular and Cellular Biochemistry, University of Kentucky, 741 S. Limestone, Lexington, KY 40536, USA

Abstract

Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.

Graphical abstract: Avobenzone incorporation in a diverse range of Ru(ii) scaffolds produces potent potential antineoplastic agents

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Article information

DOI
https://doi.org/10.1039/D0DT02016H
Article type
Communication
Submitted
05 Jun 2020
Accepted
17 Aug 2020
First published
21 Aug 2020

Dalton Trans., 2020,49, 12161-12167

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Avobenzone incorporation in a diverse range of Ru(II) scaffolds produces potent potential antineoplastic agents

R. T. Ryan, D. Havrylyuk, K. C. Stevens, L. H. Moore, D. Y. Kim, J. S. Blackburn, D. K. Heidary, J. P. Selegue and E. C. Glazer, Dalton Trans., 2020, 49, 12161 DOI: 10.1039/D0DT02016H

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