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Issue 33, 2020

Tube to ribbon transition in a self-assembling model peptide system

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Abstract

Peptides that self-assemble into β-sheet rich aggregates are known to form a large variety of supramolecular shapes, such as ribbons, tubes or sheets. However, the underlying thermodynamic driving forces for such different structures are still not fully understood, limiting their potential applications. In the AnK peptide system (A = alanine, K = lysine), a structural transition from tubes to ribbons has been shown to occur upon an increase of the peptide length, n, from 6 to 8. In this work we analyze this transition by means of a simple thermodynamic model. We consider three energy contributions to the total free energy: an interfacial tension, a penalty for deviating from the optimal β-sheet twist angle, and a hydrogen bond deformation when the β-sheets adopt a specific self-assembled structure. Whilst the first two contributions merely provide similar constant energy offsets, the hydrogen bond deformations differ depending on the studied structure. Consequently, the tube structure is thermodynamically favored for shorter AnK peptides, with a crossover at n ≈ 13. This qualitative agreement of the model with the experimental observations shows, that we have achieved a good understanding of the underlying thermodynamic features within the self-assembling AnK system.

Graphical abstract: Tube to ribbon transition in a self-assembling model peptide system

Article information


Submitted
15 Jun 2020
Accepted
06 Aug 2020
First published
06 Aug 2020

This article is Open Access

Phys. Chem. Chem. Phys., 2020,22, 18320-18327
Article type
Paper

Tube to ribbon transition in a self-assembling model peptide system

A. Rüter, S. Kuczera, J. Stenhammar, T. Zinn, T. Narayanan and U. Olsson, Phys. Chem. Chem. Phys., 2020, 22, 18320 DOI: 10.1039/D0CP03204B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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