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Issue 88, 2020
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Photoredox chemistry in the synthesis of 2-aminoazoles implicated in prebiotic nucleic acid synthesis

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Abstract

Prebiotically plausible ferrocyanide–ferricyanide photoredox cycling oxidatively converts thiourea to cyanamide, whilst HCN is reductively homologated to intermediates which either react directly with the cyanamide giving 2-aminoazoles, or have the potential to do so upon loss of HCN from the system. Thiourea itself is produced by heating ammonium thiocyanate, a product of the reaction of HCN and hydrogen sulfide under UV irradiation.

Graphical abstract: Photoredox chemistry in the synthesis of 2-aminoazoles implicated in prebiotic nucleic acid synthesis

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Supplementary files

Article information


Submitted
25 Aug 2020
Accepted
07 Oct 2020
First published
08 Oct 2020

This article is Open Access

Chem. Commun., 2020,56, 13563-13566
Article type
Communication

Photoredox chemistry in the synthesis of 2-aminoazoles implicated in prebiotic nucleic acid synthesis

Z. Liu, L. Wu, A. D. Bond and J. D. Sutherland, Chem. Commun., 2020, 56, 13563
DOI: 10.1039/D0CC05752E

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