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Issue 78, 2020
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Palladium(ii)-catalyzed asymmetric C–H carbonylation to diverse isoquinoline derivatives bearing all-carbon quaternary stereocenters

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Abstract

Enantioselective synthesis of tetrahydroisoquinolines bearing an all-carbon quaternary stereogenic center, was achieved via asymmetric C–H activation with high enantioselectivities (up to 93% ee). Fair substrate tolerance was indicated throughout the scope investigation and no evident loss of enantioselectivity was exhibited in late-stage derivatization. This study provides incentives for the construction of diverse chiral isoquinoline derivatives, which are prevalent among pharmaceuticals, natural products, etc.

Graphical abstract: Palladium(ii)-catalyzed asymmetric C–H carbonylation to diverse isoquinoline derivatives bearing all-carbon quaternary stereocenters

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Article information


Submitted
31 Jul 2020
Accepted
24 Aug 2020
First published
25 Aug 2020

Chem. Commun., 2020,56, 11605-11608
Article type
Communication

Palladium(II)-catalyzed asymmetric C–H carbonylation to diverse isoquinoline derivatives bearing all-carbon quaternary stereocenters

Y. Li, X. Cheng, F. Fei, T. Wu, K. Bian, X. Zhou and X. Wang, Chem. Commun., 2020, 56, 11605
DOI: 10.1039/D0CC05219A

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