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Issue 14, 2020
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Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR

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Abstract

G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is extremely difficult. Here, mainly by NMR, we report that colchicine selectively binds to oncogene RET G4-DNA.

Graphical abstract: Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR

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Article information


Submitted
11 Jan 2020
Accepted
24 Jan 2020
First published
27 Jan 2020

Chem. Commun., 2020,56, 2099-2102
Article type
Communication

Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR

F. Wang, C. Wang, Y. Liu, W. Lan, H. Han, R. Wang, S. Huang and C. Cao, Chem. Commun., 2020, 56, 2099
DOI: 10.1039/D0CC00221F

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