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ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

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Abstract

Gene therapy is highly suited for prostate cancer (PC). Metal–organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.

Graphical abstract: ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

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Article information


Submitted
15 Sep 2020
Accepted
30 Oct 2020
First published
30 Oct 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer

A. Poddar, S. Pyreddy, F. Carraro, S. Dhakal, A. Rassell, M. R. Field, T. S. Reddy, P. Falcaro, C. M. Doherty and R. Shukla, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC06241C

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