Issue 86, 2020

Single-cell infrared phenomics: phenotypic screening with infrared microspectroscopy

Abstract

We conceptually demonstrate single-cell infrared phenomics as a novel strategy of phenotypic screening with infrared microspectroscopy. Based on this development, the cancer cell HepG2 glycocalyx was first identified as a potential target of protopanaxadiol, an herbal medicine. These findings provide a powerful tool to accurately evaluate the cell stress response and to largely expand the phenotypic screening toolkit for drug discovery.

Graphical abstract: Single-cell infrared phenomics: phenotypic screening with infrared microspectroscopy

Supplementary files

Article information

Article type
Communication
Submitted
23 Aug 2020
Accepted
29 Sep 2020
First published
29 Sep 2020

Chem. Commun., 2020,56, 13237-13240

Single-cell infrared phenomics: phenotypic screening with infrared microspectroscopy

Y. Wang, Y. Wang, J. Qian, X. Pan, X. Li, F. Chen, J. Hu and J. Lü, Chem. Commun., 2020, 56, 13237 DOI: 10.1039/D0CC05721E

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