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Issue 77, 2020
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Visible-light-induced triple catalysis for a ring-opening cyanation of cyclopropyl ketones

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Abstract

An unprecedented triple catalytic, general ring-opening cyanation reaction of cyclopropyl ketones for the construction of γ-cyanoketones is described. The key is to merge photoredox catalysis with Lewis acid catalysis and copper catalysis to enable the selective cleavage of the carbon–carbon bonds and the selective coupling of the generated radical and cyanide anion.

Graphical abstract: Visible-light-induced triple catalysis for a ring-opening cyanation of cyclopropyl ketones

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Article information


Submitted
29 Jul 2020
Accepted
17 Aug 2020
First published
19 Aug 2020

Chem. Commun., 2020,56, 11508-11511
Article type
Communication

Visible-light-induced triple catalysis for a ring-opening cyanation of cyclopropyl ketones

J. Liu, X. Liu, H. Wu, Y. Wei, F. Lu, K. Guo, Y. Cheng and W. Xiao, Chem. Commun., 2020, 56, 11508
DOI: 10.1039/D0CC05167E

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