Jump to main content
Jump to site search

Issue 71, 2020
Previous Article Next Article

Enantioselective and regioselective aza-Friedel–Crafts reaction of electron-rich phenols with isatin-derived ketimines

Author affiliations

Abstract

An efficient asymmetric aza-Friedel–Crafts reaction of phenols with isatin-derived ketimines is described. The reaction, which was promoted by a Bi(OH)3/CPA system, gave a series of chiral 3-amino-2-oxindoles with high yields (up to 99%), excellent enantioselectivities (up to 99%) and moderate to very good regioselectivities (up to 25/1).

Graphical abstract: Enantioselective and regioselective aza-Friedel–Crafts reaction of electron-rich phenols with isatin-derived ketimines

Back to tab navigation

Associated articles

Supplementary files

Article information


Submitted
20 Jul 2020
Accepted
30 Jul 2020
First published
31 Jul 2020

Chem. Commun., 2020,56, 10361-10364
Article type
Communication

Enantioselective and regioselective aza-Friedel–Crafts reaction of electron-rich phenols with isatin-derived ketimines

L. Cai, X. Liu, J. Wang, L. Chen, X. Li and J. Cheng, Chem. Commun., 2020, 56, 10361
DOI: 10.1039/D0CC04966B

Social activity

Search articles by author

Spotlight

Advertisements