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Issue 74, 2020
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Sensitivity of VCD spectroscopy for small structural and stereochemical changes of macrolide antibiotics

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Abstract

We report the application of VCD spectroscopy for the characterization of clarithromycin and erythromycin. We show that the VCD spectra of these large macrolides are distinctly different and that spectra calculations reproduce the experimentally observed VCD signatures. In addition, computed VCD spectra of different epimers indicate that they should also be distinguishable from the correct structure of clarithromycin.

Graphical abstract: Sensitivity of VCD spectroscopy for small structural and stereochemical changes of macrolide antibiotics

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Supplementary files

Article information


Submitted
31 May 2020
Accepted
20 Jul 2020
First published
21 Jul 2020

Chem. Commun., 2020,56, 10926-10929
Article type
Communication

Sensitivity of VCD spectroscopy for small structural and stereochemical changes of macrolide antibiotics

D. P. Demarque, S. Heinrich, F. Schulz and C. Merten, Chem. Commun., 2020, 56, 10926
DOI: 10.1039/D0CC03838E

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