Issue 88, 2020
From the journal:

Chemical Communications

DNA-specific selectivity in pairing of model nucleobases in the solid state†

Tomislav Stolar, ORCID logo a   Stipe Lukin,a   Martin Etter,b   Maša Rajić Linarić,c   Krunoslav Užarević, ORCID logo a   Ernest Meštrović*d  and  Ivan Halasz ORCID logo *a  

* Corresponding authors

a Ruđer Bošković Institute, Bijenika c. 54, 10000 Zagreb, Croatia
E-mail: ivan.halasz@irb.hr

b Deutsches Elektronen-Synchrotron (DESY), 22607 Hamburg, Germany

c PLIVA Croatia Ltd, TAPI R&D, Prilaz baruna Filipovića 25, 10000 Zagreb, Croatia

d Xellia Pharmaceuticals, Slavonska avenija 24/6, 10000 Zagreb, Croatia
E-mail: ernest.mestrovic@xellia.com

Abstract

Nucleobases methylated at the glycosidic nitrogen atom achieve DNA-specific self-assembly upon heating in the solid state. We report formation and characterisation of the elusive cocrystal of methylated guanine and methylated cytosine, exhibiting Watson–Crick-type hydrogen bonding, and the crystal structure of 9-methylguanine.

Graphical abstract: DNA-specific selectivity in pairing of model nucleobases in the solid state

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Article information

DOI
https://doi.org/10.1039/D0CC03491F
Article type
Communication
Submitted
15 May 2020
Accepted
02 Sep 2020
First published
09 Sep 2020

Chem. Commun., 2020,56, 13524-13527

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DNA-specific selectivity in pairing of model nucleobases in the solid state

T. Stolar, S. Lukin, M. Etter, M. Rajić Linarić, K. Užarević, E. Meštrović and I. Halasz, Chem. Commun., 2020, 56, 13524 DOI: 10.1039/D0CC03491F

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