Issue 72, 2020
From the journal:

Chemical Communications

Toward supramolecular nanozymes for the photocatalytic activation of Pt(iv) anticancer prodrugs†

Laura F. Mazzei,abc   Álvaro Martínez,*a   Lucia Trevisan, ORCID logo c   Daniele Rosa-Gastaldo, ORCID logo c   Aitziber L. Cortajarena, ORCID logo bd   Fabrizio Mancin ORCID logo *c  and  Luca Salassa ORCID logo *ade  

* Corresponding authors

a Donostia International Physics Center, Paseo Manuel de Lardizabal 4, Donostia, Spain
E-mail: lsalassa@dipc.org

b CIC biomaGUNE, Basque Research Technology Alliance, BRTA, Parque Tecnológico de San Sebastián, Paseo Miramón 194, 20014 Donostia/San Sebastián, Spain

c Dipartimento di Scienze Chimiche, Università di Padova, via Marzolo 1, Padova, Italy
E-mail: fabrizio.mancin@unipd.it

d Ikerbasque, Basque Foundation for Science, Bilbao, Spain

e Kimika Fakultatea, Euskal Herriko Unibertsitatea, UPV/EHU, Donostia, Spain

Abstract

A supramolecular nanozyme for the photocatalytic conversion of a Pt(IV) anticancer complex to cisplatin is described herein. We employed 1.9 nm Au nanoparticles decorated with thiol ligands bearing a TACN (1,4,7-triazacyclononane) headgroup to encapsulate FMN (riboflavin-5′-phosphate). In the presence of an electron donor, flavin-loaded nanoparticles photocatalyzed the reductive activation of the prodrug cis,cis,trans-[Pt(NH3)2(Cl2)(O2CCH2CH2COOH)2] to cisplatin, achieving turnover frequency values of 7.4 min−1.

Graphical abstract: Toward supramolecular nanozymes for the photocatalytic activation of Pt(iv) anticancer prodrugs

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Article information

DOI
https://doi.org/10.1039/D0CC03450A
Article type
Communication
Submitted
14 May 2020
Accepted
28 Jul 2020
First published
02 Sep 2020
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2020,56, 10461-10464

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Toward supramolecular nanozymes for the photocatalytic activation of Pt(IV) anticancer prodrugs

L. F. Mazzei, Á. Martínez, L. Trevisan, D. Rosa-Gastaldo, A. L. Cortajarena, F. Mancin and L. Salassa, Chem. Commun., 2020, 56, 10461 DOI: 10.1039/D0CC03450A

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