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Conjugate Sn(IV)(pyropheophorbide a)dichloride–(peptide nucleic acid) catalyzes reduction of azobenzene derivatives in the presence of complementary nucleic acid (NA) upon irridiation with red light (660 nm). This is the first red light-induced NA-templated photoreduction. It is highly sensitive to single mismatches in the NA-template and can detect down to 5 nM NAs.

Graphical abstract: Red light-triggered photoreduction on a nucleic acid template

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