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Issue 58, 2020

Tuning the antimicrobial activity of low molecular weight hydrogels using dopamine autoxidation

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Abstract

We present a method to trigger the formation of dipeptide-based hydrogels by the simple addition of dopamine. Dopamine undergoes oxidation in air, reducing the pH to induce gelation. The production of polydopamine and release of reactive oxygen species such as hydrogen peroxide confers antimicrobial activity. Gel stiffness can be controlled by modulating the initial starting pH of the gelator solution. We can use this method to tune the antimicrobial activity of the gels, with gels that are less stiff demonstrating increased bactericidal efficacy against Gram-positive bacteria.

Graphical abstract: Tuning the antimicrobial activity of low molecular weight hydrogels using dopamine autoxidation

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Article information


Submitted
09 Apr 2020
Accepted
10 Jun 2020
First published
10 Jun 2020

This article is Open Access

Chem. Commun., 2020,56, 8135-8138
Article type
Communication

Tuning the antimicrobial activity of low molecular weight hydrogels using dopamine autoxidation

E. R. Cross, S. M. Coulter, A. M. Fuentes-Caparrós, K. McAulay, R. Schweins, G. Laverty and D. J. Adams, Chem. Commun., 2020, 56, 8135 DOI: 10.1039/D0CC02569K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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