Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Nayara Braga Emidio; Hayeon Baik; David Lee; René Stürmer; Jörn Heuer; Alysha G. Elliott; Mark A. T. Blaskovich; Katharina Haupenthal; Nicole Tegtmeyer; Werner Hoffmann; Christina I. Schroeder; Markus Muttenthaler

doi:10.1039/D0CC02321C

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action†

Nayara Braga Emidio,

^a Hayeon Baik,^b David Lee,^a René Stürmer,^c Jörn Heuer,^c Alysha G. Elliott,

^a Mark A. T. Blaskovich,

^a Katharina Haupenthal,^c Nicole Tegtmeyer,^d Werner Hoffmann,^c Christina I. Schroeder

^ae and Markus Muttenthaler

*^ab

Author affiliations

* Corresponding authors

^a Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia

^b Institute of Biological Chemistry, Faculty of Chemistry, University of Vienna, Währingerstr. 38, Vienna, Austria
E-mail: markus.muttenthaler@univie.ac.at

^c Institute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany

^d Division of Microbiology, Department of Biology, Friedrich-Alexander-University, Erlangen-Nürnberg Staudtstr. 5, 91058 Erlangen, Germany

^e National Cancer Institute, National Institutes of Health, Frederick, MD, USA

Abstract

TFF1 is a key peptide for gastrointestinal protection and repair. Its molecular mechanism of action remains poorly understood with synthetic intractability a recognised bottleneck. Here we describe the synthesis of TFF1 and its homodimer and their interactions with mucins and Helicobacter pylori. Synthetic access to TFF1 is an important milestone for probe and therapeutic development.

Chemical Communications

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action†

Abstract

Associated articles

Supplementary files

Article information

Download Citation

Permissions

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Social activity

Search articles by author

Spotlight

Advertisements