Issue 47, 2020

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Abstract

TFF1 is a key peptide for gastrointestinal protection and repair. Its molecular mechanism of action remains poorly understood with synthetic intractability a recognised bottleneck. Here we describe the synthesis of TFF1 and its homodimer and their interactions with mucins and Helicobacter pylori. Synthetic access to TFF1 is an important milestone for probe and therapeutic development.

Graphical abstract: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Associated articles

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Article information

Article type
Communication
Submitted
31 Mar 2020
Accepted
30 Apr 2020
First published
30 Apr 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 6420-6423

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

N. Braga Emidio, H. Baik, D. Lee, R. Stürmer, J. Heuer, A. G. Elliott, M. A. T. Blaskovich, K. Haupenthal, N. Tegtmeyer, W. Hoffmann, C. I. Schroeder and M. Muttenthaler, Chem. Commun., 2020, 56, 6420 DOI: 10.1039/D0CC02321C

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