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Issue 41, 2020
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Red-light-sensitive BODIPY photoprotecting groups for amines and their biological application in controlling heart rhythm

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Abstract

Control of biological function by the use of photoremovable protecting groups (PPGs) is a gateway towards many new medical developments. Herein, we report the synthesis and application of efficient and biocompatible BODIPY-based photoprotecting groups for amines, which are cleavable with red light in the phototherapeutic window region (λ > 650 nm). We use the most promising PPG for the protection of dopamine and apply it to control the beating frequency of human cardiomyocytes.

Graphical abstract: Red-light-sensitive BODIPY photoprotecting groups for amines and their biological application in controlling heart rhythm

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Supplementary files

Article information


Submitted
24 Mar 2020
Accepted
20 Apr 2020
First published
20 Apr 2020

This article is Open Access

Chem. Commun., 2020,56, 5480-5483
Article type
Communication

Red-light-sensitive BODIPY photoprotecting groups for amines and their biological application in controlling heart rhythm

K. Sitkowska, M. F. Hoes, M. M. Lerch, L. N. Lameijer, P. van der Meer, W. Szymański and B. L. Feringa, Chem. Commun., 2020, 56, 5480
DOI: 10.1039/D0CC02178D

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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