Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 49, 2020
Previous Article Next Article

Teaching old indicators even more tricks: binding affinity measurements with the guest-displacement assay (GDA)

Author affiliations

Abstract

A simple change has important consequences: the guest-displacement assay (GDA) is introduced which allows for binding affinity determinations of supramolecular complexes with spectroscopically silent hosts and guests. GDA is complementary to indicator-displacement assay for affinity measurements with soluble components, but is superior for insoluble or for weakly binding guests.

Graphical abstract: Teaching old indicators even more tricks: binding affinity measurements with the guest-displacement assay (GDA)

Back to tab navigation

Supplementary files

Article information


Submitted
10 Mar 2020
Accepted
28 Apr 2020
First published
01 May 2020

This article is Open Access

Chem. Commun., 2020,56, 6620-6623
Article type
Communication

Teaching old indicators even more tricks: binding affinity measurements with the guest-displacement assay (GDA)

S. Sinn, J. Krämer and F. Biedermann, Chem. Commun., 2020, 56, 6620
DOI: 10.1039/D0CC01841D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements