Jump to main content
Jump to site search

Issue 38, 2020
Previous Article Next Article

Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

Author affiliations

Abstract

We report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate the robust visible-light mediated switching of the G4 ligand binding mode and G-tetrad structure in physiologically-relevant conditions. The toxicity of the ligand to cervical cancer cells is modulated by the photoisomeric state of the ligand, indicating for the first time the potential of G4 to serve as a target for photopharmacological strategies.

Graphical abstract: Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

Back to tab navigation

Supplementary files

Article information


Submitted
28 Feb 2020
Accepted
18 Mar 2020
First published
08 Apr 2020

Chem. Commun., 2020,56, 5186-5189
Article type
Communication

Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

M. P. O’Hagan, J. Ramos-Soriano, S. Haldar, S. Sheikh, J. C. Morales, A. J. Mulholland and M. C. Galan, Chem. Commun., 2020, 56, 5186
DOI: 10.1039/D0CC01581D

Social activity

Search articles by author

Spotlight

Advertisements