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Issue 27, 2020

Highly efficient photocontrolled targeted delivery of siRNA by a cyclodextrin-based supramolecular nanoassembly

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Abstract

In this study, we have constructed a binary supramolecular nanoassembly composed of α-cyclodextrin-modified hyaluronic acid and an azobenzene-modified diphenylalanine derivative with a positively charged imidazole group. This nanoassembly can bind with siRNA through electrostatic interactions and efficiently delivered them into cancer cells and inhibited their growth.

Graphical abstract: Highly efficient photocontrolled targeted delivery of siRNA by a cyclodextrin-based supramolecular nanoassembly

Supplementary files

Article information


Submitted
23 Jan 2020
Accepted
28 Feb 2020
First published
28 Feb 2020

Chem. Commun., 2020,56, 3907-3910
Article type
Communication

Highly efficient photocontrolled targeted delivery of siRNA by a cyclodextrin-based supramolecular nanoassembly

F. Li, Q. Yu, Y. Liu, H. Yu, Y. Chen and Y. Liu, Chem. Commun., 2020, 56, 3907 DOI: 10.1039/D0CC00629G

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