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Issue 34, 2020
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Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2

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Abstract

A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [11C]CO2 and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [11C]CO2 delivery with a trapping efficiency of 21–89%.

Graphical abstract: Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2

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Article information


Submitted
16 Jan 2020
Accepted
10 Feb 2020
First published
25 Mar 2020

This article is Open Access

Chem. Commun., 2020,56, 4668-4671
Article type
Communication

Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2

S. Bongarzone, N. Raucci, I. C. Fontana, F. Luzi and A. D. Gee, Chem. Commun., 2020, 56, 4668
DOI: 10.1039/D0CC00449A

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