Issue 16, 2020
From the journal:

Chemical Communications

Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo†

Min Li,‡a   Chuanfeng Wang,‡a   Ting Wang, ORCID logo *b   Mengting Fan,a   Ning Wang,a   Danying Ma,a   Ting Hua  and  Xiaoyan Cui ORCID logo *a  

* Corresponding authors

a Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, P. R. China
E-mail: xycui@chem.ecnu.edu.cn

b College of Pharmacy, Second Military Medical University, Shanghai, P. R. China

Abstract

A group of asymmetric Si-rhodamine scaffolds was designed for protease-activated NIR probes. Dual pH-inertia for both spirocyclized fluorescent probes and fluorescent products of zwitterions form over a wide range of pH (4.0–11.0). Leucine aminopeptidase (LAP) and γ-glutamyl transpeptidase (GGT) were monitored by fluorescent imaging in vivo.

Graphical abstract: Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo

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Article information

DOI
https://doi.org/10.1039/C9CC09666C
Article type
Communication
Submitted
12 Dec 2019
Accepted
14 Jan 2020
First published
16 Jan 2020

Chem. Commun., 2020,56, 2455-2458

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Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo

M. Li, C. Wang, T. Wang, M. Fan, N. Wang, D. Ma, T. Hu and X. Cui, Chem. Commun., 2020, 56, 2455 DOI: 10.1039/C9CC09666C

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