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Issue 4, 2020
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Concise gram-scale synthesis of Euphorikanin A skeleton through a domino ring-closing metathesis strategy

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Abstract

Euphorikanin A is a diterpenoid possessing a highly congested and unprecedented 5/6/7/3-fused tetracyclic ring skeleton. To access the challenging chemical structure of Euphorikanins, an efficient total synthetic approach is described. The stereoselective synthesis of the core structure of Euphorikanin A has been achieved from a simple dienyne building block, and a domino ring-closing metathesis (RCM) strategy was used for the gram-scale synthesis of the highly strained Euphorikanin A core. This paves the way for the synthesis of structurally diverse Euphorikanins.

Graphical abstract: Concise gram-scale synthesis of Euphorikanin A skeleton through a domino ring-closing metathesis strategy

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Article information


Submitted
12 Nov 2019
Accepted
02 Dec 2019
First published
06 Dec 2019

Chem. Commun., 2020,56, 531-534
Article type
Communication

Concise gram-scale synthesis of Euphorikanin A skeleton through a domino ring-closing metathesis strategy

L. Shi, Y. He, J. Gong and Z. Yang, Chem. Commun., 2020, 56, 531
DOI: 10.1039/C9CC08830J

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