Issue 10, 2020

A palladium-catalyst stabilized in the chiral environment of a monoclonal antibody in water

Abstract

We report the first preparation of a monoclonal antibody (mAb) that can immobilize a palladium (Pd)-complex. The allylic amination reaction using a supramolecular catalyst consisting of the Pd-complex and mAb selectively gives the (R)-enantiomer product with an enantiomeric excess (ee) of 98 ± 2%. This is in sharp contrast to the reaction catalyzed by a conventional Pd-catalyst (ee < 2%).

Graphical abstract: A palladium-catalyst stabilized in the chiral environment of a monoclonal antibody in water

Supplementary files

Article information

Article type
Communication
Submitted
09 Nov 2019
Accepted
06 Jan 2020
First published
06 Jan 2020
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2020,56, 1605-1607

A palladium-catalyst stabilized in the chiral environment of a monoclonal antibody in water

Y. Kobayashi, K. Murata, A. Harada and H. Yamaguchi, Chem. Commun., 2020, 56, 1605 DOI: 10.1039/C9CC08756G

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