Metal-free α-arylation of α-fluoro-α-nitroacetamides employing diaryliodonium salts

Abstract

Herein, we present a mild and efficient metal-free arylation of α-fluoro-α-nitroacetamides employing diaryliodonium salts. A broad range of diaryliodonium salts and α-fluoro-α-nitroacetamides containing sensitive functional groups was successfully employed in this protocol to yield the arylated products in good yields. The synthetic value of this novel protocol was further highlighted by extending the α-arylation to α-cyano-α-fluoroacetamides.