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Issue 3, 2020
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Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors

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Abstract

We herein report a new approach for RNA interference, so-called “build-up RNAi” approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors. The advantages of using these circular RNA formats for RNAi were presented in aspects of immunogenicity and cellular uptake.

Graphical abstract: Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors

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Supplementary files

Article information


Submitted
25 Jun 2019
Accepted
02 Dec 2019
First published
02 Dec 2019

Chem. Commun., 2020,56, 466-469
Article type
Communication

Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors

Y. Kimura, Z. Shu, M. Ito, N. Abe, K. Nakamoto, F. Tomoike, S. Shuto, Y. Ito and H. Abe, Chem. Commun., 2020, 56, 466
DOI: 10.1039/C9CC04872C

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