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Issue 2, 2020
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Synthetic hyperacetylation of nucleosomal histones

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Abstract

We report combinations of a DMAP-based catalyst and phenyl acetate with optimal electron density as a new chemical system for high-yield, selective synthetic acetylation of histone lysine residues. The utility of this chemical system as a unique biologic tool is demonstrated by applying it to Xenopus laevis sperm chromatin.

Graphical abstract: Synthetic hyperacetylation of nucleosomal histones

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Article information


Submitted
11 Mar 2020
Accepted
29 Apr 2020
First published
19 May 2020

This article is Open Access

RSC Chem. Biol., 2020,1, 56-59
Article type
Communication

Synthetic hyperacetylation of nucleosomal histones

H. Kajino, T. Nagatani, M. Oi, T. Kujirai, H. Kurumizaka, A. Nishiyama, M. Nakanishi, K. Yamatsugu, S. A. Kawashima and M. Kanai, RSC Chem. Biol., 2020, 1, 56
DOI: 10.1039/D0CB00029A

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