Issue 9, 2020

Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration

Abstract

Bone regeneration is a complex process in which angiogenesis and osteogenesis are crucial. Introducing multiple angiogenic and osteogenic cues simultaneously into a single system and tuning these cues to optimize the niche remains a challenge for bone tissue engineering. Herein, based on our injectable biomimetic hydrogels composed of silk nanofibers (SNF) and hydroxyapatite nanoparticles (HA), deferoxamine (DFO) and bone morphogenetic protein-2 (BMP-2) were loaded on SNF and HA to introduce more angiogenic and osteogenic cues. The angiogenesis and osteogenesis capacity of injectable hydrogels could be regulated by tuning the delivery of DFO and BMP-2 independently, resulting in vascularization and bone regeneration in cranial defects. The angiogenesis and osteogenesis outcomes accelerated the regeneration of vascularized bones toward similar composition and structure to natural bones. Therefore, the multiple biophysical and chemical cues provided by the nanofibrous structures, organic–inorganic compositions, and chemical and biochemical angiogenic and osteogenic inducing cues suggest the potential for clinical applicability of these hydrogels in bone tissue engineering.

Graphical abstract: Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration

Supplementary files

Article information

Article type
Paper
Submitted
19 Jan 2020
Accepted
18 Mar 2020
First published
19 Mar 2020

Biomater. Sci., 2020,8, 2537-2548

Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration

W. Cheng, Z. Ding, X. Zheng, Q. Lu, X. Kong, X. Zhou, G. Lu and D. L. Kaplan, Biomater. Sci., 2020, 8, 2537 DOI: 10.1039/D0BM00104J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements