Issue 13, 2020

Acid–base titration using a microfluidic thread-based analytical device (μTAD)

Abstract

This work presents the development and application of a novel analytical approach for the determination of acid and base concentrations by titration using a microfluidic thread-based analytical device (μTAD). This approach proved to be a simple to fabricate and to use, high precision, and cost-efficient means of acid–base quantification. The μTAD was fabricated by immobilizing the untreated cotton threads onto a wood frame, followed by pre-coating with an indicator (20 μL) and a primary standard solution (3 μL), and was tested using real samples including drug, food, and household products where 3 μL of each sample was dropped onto the center of a thread. Afterward, the distance of color change on the thread, easily observed and measured using the naked eye and a ruler, was used for analysis. The analysis using the μTAD, completed within 2 minutes and validated by the conventional titration, showed high accuracy and precision (RSD < 12.9%), good linearity ranges and low limit of quantification. The fabricated μTAD also remained stable for an extended period of time (>2 weeks under various storage conditions).

Graphical abstract: Acid–base titration using a microfluidic thread-based analytical device (μTAD)

Supplementary files

Article information

Article type
Paper
Submitted
14 Mar 2020
Accepted
04 May 2020
First published
04 May 2020

Analyst, 2020,145, 4457-4466

Acid–base titration using a microfluidic thread-based analytical device (μTAD)

P. Jarujamrus, A. Prakobkij, S. Puchum, S. Chaisamdaeng, R. Meelapsom, W. Anutrasakda, M. Amatatongchai, S. Chairam and D. Citterio, Analyst, 2020, 145, 4457 DOI: 10.1039/D0AN00522C

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