Comment on “Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use” by D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489

Michael E. Mullins; Mark C. Yarema; Marco L. A. Sivilotti; Margaret Thompson; D. Adam Algren; Michael C. Beuhler; Christopher P. Holstege

doi:10.1039/C9TX00158A

Comment on “Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use” by D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489

Michael E. Mullins,

*^a Mark C. Yarema,

^b Marco L. A. Sivilotti,

^c Margaret Thompson,^d D. Adam Algren,

^e Michael C. Beuhler^f and Christopher P. Holstege^g

Author affiliations

* Corresponding authors

^a Section of Medical Toxicology, Division of Emergency Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA
E-mail: mullinsm@wustl.edu

^b Poison and Drug Information Service, Alberta Health Services, Calgary, Alberta, Canada

^c Department of Emergency Medicine, Queen's University, Kingston, Ontario, Canada

^d Ontario Poison Centre, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Kids, Toronto, Ontario, Canada

^e Department of Emergency Medicine, Children's Mercy Medical Center, Kansas City, Missouri, USA

^f North Carolina Poison Center, Atrium Health-Carolinas Medical Center, Charlotte, North Carolina, USA

^g Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia School of Medicine, Chartottesville, Virginia, USA

Abstract

We point out an acetylcysteine protocol that a previous article (D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489–498) overlooked. The standard concentration protocol uses a uniform concentration of 30 mg mL⁻¹ for all patients to reduce errors in preparation and administration. Usually a single 1 L bag is sufficient for most patients. Various centers in the US and Canada use this approach.

Toxicology Research

Comment on “Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use” by D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489

Abstract

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