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PM2.5 induces neurodegeneration-like changes in mice and antagonsistc effects of vitamin E

Abstract

Neurodegenerative diseases (ND), affect a large and ever-growing population globally, has resulted in heavy burdens for patients and their families. Though the some specific genes related to ND have been identified, the genetic factors fail to fully account for the pathogenesis of ND. Therefore, the roles of environment and life styles in the occurrence of ND are being actively probed. As a typical air pollutant, exposures to PM2.5 bear certain relevance to the occurrence of ND. But there are still few researches on this exposure, especially on the in vivo and molecular mechanisms of the ND-like lesions after PM2.5 exposure. To determine the objective, C57BL/6J mice were exposed daily to PM2.5 for one week. Then brian damages and upstream events were investigated. After acute PM2.5 exposure, some ND-like changes were detected, such as cognitive deficits, loss of neurons, protein aggregates, etc. Oxidative stress and inflammation may be involved into the toxic mechanisms. These effects were blocked by concurrent administration of vitamin E (Vit E). Down-regulation of oxidative stress and inflammation were proposed to explain the antagonsistc effects of Vit E.

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Publication details

The article was received on 08 Dec 2018, accepted on 07 Jan 2019 and first published on 08 Jan 2019


Article type: Paper
DOI: 10.1039/C8TX00333E
Citation: Toxicol. Res., 2019, Accepted Manuscript
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    PM2.5 induces neurodegeneration-like changes in mice and antagonsistc effects of vitamin E

    X. X. Liu, Y. Zhang and X. Yang, Toxicol. Res., 2019, Accepted Manuscript , DOI: 10.1039/C8TX00333E

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