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A review of arsenic exposure and lung cancer

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Abstract

As a well-established human carcinogen, arsenic has increased the risk of lung cancer over the past decades. Wide exposure to arsenic in the environment has attracted the attention of scientists. Its carcinogenicity at early life stages has been observed in certain animal studies already, yet current evidence is insufficient to extrapolate this to humans. Although the mechanisms of lung cancer induced by arsenic remain unclear, most of them are related to the biotransformation of arsenic, which would further provide target sites for precaution and therapy. This review comprehensively summarizes current studies associated to arsenic exposure and lung cancer and the mechanism of its carcinogenesis in lung cancer in three sections, namely, epidemiological studies, experimental studies, and mechanistic studies. In addition, prevention and treatment strategies as well as directions for future studies are discussed.

Graphical abstract: A review of arsenic exposure and lung cancer

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Publication details

The article was received on 02 Nov 2018, accepted on 22 Jan 2019 and first published on 23 Jan 2019


Article type: Review Article
DOI: 10.1039/C8TX00298C
Citation: Toxicol. Res., 2019, Advance Article

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    A review of arsenic exposure and lung cancer

    S. Wei, H. Zhang and S. Tao, Toxicol. Res., 2019, Advance Article , DOI: 10.1039/C8TX00298C

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