G-quadruplex DNA regulates invertible circularly polarized luminescence
Circularly polarized luminescence (CPL) has recently attracted great interests due to the chiral optical applications; vaious materials are developed as templates for CPL readout. Here we demonstrate firstly CPL measurement from human telomeric G-quadruplex (Tel G4) and achiral fluorogenic dye (ThT) interaction, in which the chirality transferred from G4 template to the molecules binding. Chiral CPL signals are sensitive to Tel G4 structures, not only the mirror D-/L- enantiomers, but also parallel/antiparallel dynamic changes. Different DNA sequences and structures are statistically analysed to draw a conclusion that right-handed CPL is induced on parallel G4 structure, otherwise the left-handed CPL is triggered on antiparallel G4 with opposite chirality directions. Inversion of polarity of G-quartets in various G4s would change the chiroptical phenomenon as same induced Cotton effect as in CD. Furthermore, invertible CPL signals can be regulated by metal ion and temperature with stimuli-responsive activities, revealing the convenient and dynamic CPL signals based on G4 polymorphism.