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SERS detection of glucose using graphene oxide-wrapped gold nanobones with silver coating


Abstract In this work, we prepared graphene oxide (GO) decorated silver-coated gold nanobones (AuNBs@Ag@GO) for optimal surface enhanced Raman scattering (SERS) activity. 4-MBA was adsorbed on the interface between gold and silver to provide more space of outer Ag surface for GO decoration. Silver was deposited on the middle and end surface of gold nanobones (AuNBs) with negative curvature and formed stubby bimetallic nanocuboids inducing the transverse surface plasmon resonance (SPR) and middle SPR merged into a new plasmon resonance. SERS activity of the silver-coated gold nanobones (AuNBs@Ag) changed non-monotonically with the increase of silver coating, and reached up to 8 times greater than that of bare AuNBs, which performing better than silver-coated gold nanorods (AuNRs@Ag). GO hybridized with AuNBs@Ag by electrostatic adherence could further improve the SERS activity of AuNBs@Ag, and the concentration of GO was adjusted for the best SERS performance which was 4 times greater than that of naked AuNBs@Ag. The AuNBs@Ag@GO can be used as a SERS substrate to detect the glucose in urine. The mechanism is that the high concentration of liquid glucose induced large density covers and forms a glucose partition layer on the AuNBs@Ag@GO substrate, and with the increase of the glucose concentration, the thickness of the glucose partition layer increased, so it can decay the intensity of incident light and resulte to the Raman signal of 4-MBA fade down. What’s more, the strong SERS activity of the AuNBs@Ag@GO substrate can provide wider space to achieve the lower LOD of glucose. The intensity of characteristic Raman peak at 1585 cm-1 was linearly decreased with glucose concentration increasing in the range of 10~107 nmol/L with a low LOD (S/N=3) of 2.61 nmol/L. At the same time, the SERS substrate is proved to be selective and reliable and shows the great potential and broad applications in glucose detection.

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Publication details

The article was received on 26 Nov 2018, accepted on 12 Feb 2019 and first published on 13 Feb 2019

Article type: Paper
DOI: 10.1039/C8TC05942J
Citation: J. Mater. Chem. C, 2019, Accepted Manuscript

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    SERS detection of glucose using graphene oxide-wrapped gold nanobones with silver coating

    J. Zhu, H. Du, Q. Zhang, J. Zhao, G. Weng, J. Li and J. Zhao, J. Mater. Chem. C, 2019, Accepted Manuscript , DOI: 10.1039/C8TC05942J

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