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Two spirobifluorene-based fluorescent probes with aggregation-induced emission properties: synthesis and application in the detection of Zn2+ and cell imaging

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Abstract

In this work, two spirobifluorene-based probes, namely SPF-1 and SPF-2, were designed and synthesized. They exhibited high selectivity and sensitivity toward Zn2+ with enhanced emissions, which could be attributed to the formation of an L–Zn complex. The detection limit of SPF-2 is 63 nM for Zn2+ and this is significantly lower than most previous reports. SPF-1 was successfully used for intracellular Zn2+ imaging. In addition, SPF-2 possesses two-photon absorption properties and has been applied in two-photon fluorescence cell imaging. This study is the first time that a spirobifluorene-based probe with aggregation-induced emission enhancement (AIEE) properties has been reported. We hope that this molecular design triggers further interest in using spiro-configured compounds in AIEE-based bioprobes for further applications.

Graphical abstract: Two spirobifluorene-based fluorescent probes with aggregation-induced emission properties: synthesis and application in the detection of Zn2+ and cell imaging

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Publication details

The article was received on 03 Nov 2018, accepted on 18 Jan 2019 and first published on 21 Jan 2019


Article type: Paper
DOI: 10.1039/C8TC05526B
Citation: J. Mater. Chem. C, 2019, Advance Article

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    Two spirobifluorene-based fluorescent probes with aggregation-induced emission properties: synthesis and application in the detection of Zn2+ and cell imaging

    J. Wan, W. Zhang, H. Guo, J. Liang, D. Huang and H. Xiao, J. Mater. Chem. C, 2019, Advance Article , DOI: 10.1039/C8TC05526B

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