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Near-infrared light and magnetic field dual-responsive porous silicon-based nanocarriers to overcome multi-drug resistance of breast cancer cells with enhanced efficiency

Abstract

The development of drug delivery systems based on external stimuli-responsive nanocarriers is important to overcome multidrug resistance of breast cancer cells. Herein, iron oxide/gold (Fe3O4/Au) nanoparticles were first fabricated via a simple hydrothermal reaction, and subsequently loaded into porous silicon nanoparticles (PSiNPs) via electrostatic interactions to construct PSiNPs@(Fe3O4/Au) nanocomposites. As-prepared PSiNPs@(Fe3O4/Au) nanocomposites exhibited excellent super-paramagnetism, photothermal effect, and T2-weight magnetic resonance imaging capability. Particularly, with the help of magnetic field, the cellular uptake of PSiNPs@(Fe3O4/Au) nanocomposites was significantly enhanced in drug-resistant breast cancer cells. Moreover, PSiNPs@(Fe3O4/Au) nanocomposites as carriers showed a high loading and NIR light-triggered release of anticancer drug. Based on the synergistic effect of magnetic field-enhanced cellular uptake and NIR light-triggered intracellular release, the amount of anticancer drug carried by PSiNPs@(Fe3O4/Au) nanocarriers into the nuclei of drug-resistant breast cancer cells sharply increased, accompanied with improved chemo-photothermal therapeutic efficacy. Finally, PSiNPs@(Fe3O4/Au) nanocomposites under the combination conditions of magnetic field attraction and NIR light irradiation also showed improved anticancer drug penetration and accumulation in three-dimensional multicellular spheroids composed of drug-resistant breast cancer cells, leading to better growth inhibition effect. Overall, the fabricated PSiNPs@(Fe3O4/Au) nanocomposites demonstrated great potential for the therapy of multidrug-resistant breast cancer in future.

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Publication details

The article was received on 23 Oct 2019, accepted on 03 Dec 2019 and first published on 03 Dec 2019


Article type: Paper
DOI: 10.1039/C9TB02340B
J. Mater. Chem. B, 2019, Accepted Manuscript

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    Near-infrared light and magnetic field dual-responsive porous silicon-based nanocarriers to overcome multi-drug resistance of breast cancer cells with enhanced efficiency

    J. Li, W. Zhang, Y. Gao, H. Tong, Z. Chen, J. Shi, H. A. Santos and B. Xia, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C9TB02340B

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