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Remodeling tumor microenvironment to improve drug permeation and antitumor effects by co-delivering quercetin and doxorubicin

Abstract

In our study, a hyaluronic acid (HA) modified zeolitic imidazolate framework (ZIF) was successfully fabricated (HA/ZIF) and employed to load doxorubicin (Dox) and quercetin (Que) simultaneously for cancer therapy. The QUE and DOX co loaded HA/ZIF (HA/ZIF/DQ) showed preferable stability under physiological conditions, pH responsive drug release under acidic environment and preferable homing capacity to CD44 receptor over expressed HepG2/ADR cells. More importantly, our results revealed that the enhanced anticancer efficacy was achieved through the combination of Que and Dox via the remodeling the tumor microenvironment effect of Que to potentiate the drug penetration into deep tumor tissue.

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Publication details

The article was received on 29 Sep 2019, accepted on 23 Oct 2019 and first published on 09 Nov 2019


Article type: Paper
DOI: 10.1039/C9TB02131K
J. Mater. Chem. B, 2019, Accepted Manuscript

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    Remodeling tumor microenvironment to improve drug permeation and antitumor effects by co-delivering quercetin and doxorubicin

    M. Li, X. Yue, Y. Wang, J. Zhang, L. Kan and Z. Jing, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C9TB02131K

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