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Critical and diverse roles of phosphates in human bone formation

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Abstract

Humans utilise biomineralisation in the formation of bone and teeth. Human biomineralisation processes are defined by the transformation of an amorphous phosphate-based precursor to highly organised nanocrystals. Interestingly, ionic phosphate species not only provide a fundamental building block of biological mineral, but rather exhibit several diverse roles in mediating mineral formation in the physiological milieu. In this review, we focus on elucidating the complex roles of phosphate ions and molecules within human biomineralisation pathways, primarily referring to the nucleation and crystallisation of bone mineral.

Graphical abstract: Critical and diverse roles of phosphates in human bone formation

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Publication details

The article was received on 16 Sep 2019, accepted on 29 Oct 2019 and first published on 01 Nov 2019


Article type: Review Article
DOI: 10.1039/C9TB02011J
J. Mater. Chem. B, 2019, Advance Article
  • Open access: Creative Commons BY license
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    Critical and diverse roles of phosphates in human bone formation

    E. A. B. Hughes, T. E. Robinson, D. B. Bassett, S. C. Cox and L. M. Grover, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB02011J

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