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Issue 47, 2019
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Critical and diverse roles of phosphates in human bone formation

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Abstract

Humans utilise biomineralisation in the formation of bone and teeth. Human biomineralisation processes are defined by the transformation of an amorphous phosphate-based precursor to highly organised nanocrystals. Interestingly, ionic phosphate species not only provide a fundamental building block of biological mineral, but rather exhibit several diverse roles in mediating mineral formation in the physiological milieu. In this review, we focus on elucidating the complex roles of phosphate ions and molecules within human biomineralisation pathways, primarily referring to the nucleation and crystallisation of bone mineral.

Graphical abstract: Critical and diverse roles of phosphates in human bone formation

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Article information


Submitted
16 Sep 2019
Accepted
29 Oct 2019
First published
01 Nov 2019

This article is Open Access

J. Mater. Chem. B, 2019,7, 7460-7470
Article type
Review Article

Critical and diverse roles of phosphates in human bone formation

E. A. B. Hughes, T. E. Robinson, D. B. Bassett, S. C. Cox and L. M. Grover, J. Mater. Chem. B, 2019, 7, 7460
DOI: 10.1039/C9TB02011J

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