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Therapeutics transdermal delivery through dissolvable gelatin/sucrose film coated on PEGDA microneedle array with improved skin permeability

Abstract

Microneedles are primarily designed for enhancing transdermal drug delivery in a minimally invasive manner. In particular, coated microneedles have captured increasing attention owing to the resulted mode of rapid and highly efficient drug administration. In this study, we developed a novel gelatin/sucrose film-coated poly(ethylene glycol) diacrylate (PEGDA) microneedle patch, which can effectively improve skin permeability of therapeutic drug and realize convenient and efficient drug administration. A simple and reliable technique was proposed to produce uniform film coating on microneedles at room temperature. After introducing a prepolymer solution into the mold cavity, film-coated microneedle patch was fabricated via a photo-induced polymerization process. Four categories of molecule models, including Rhodamine B (RhB), bovine serum albumin (BSA), doxorubicin (DOX) and indocyanine green (ICG), were encapsulated into the gelatin/sucrose film to evaluate their transdermal delivery and therapeutic effects both in vitro and in vivo. The presented methodology represents a facile technique for rapid formation of film-coated microneedles for efficient transdermal delivery of small molecular drugs and large proteins.

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Publication details

The article was received on 12 Sep 2019, accepted on 23 Oct 2019 and first published on 25 Oct 2019


Article type: Paper
DOI: 10.1039/C9TB01994D
J. Mater. Chem. B, 2019, Accepted Manuscript

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    Therapeutics transdermal delivery through dissolvable gelatin/sucrose film coated on PEGDA microneedle array with improved skin permeability

    Y. Gao, M. Hou, R. Yang, L. Zhang, Z. Xu, Y. Kang and P. Xue, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C9TB01994D

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