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Issue 46, 2019
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A mitochondria-targeted fluorescent probe based on coumarin–pyridine derivatives for hypochlorite imaging in living cells and zebrafish

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Abstract

Hypochlorite plays a critical role in various physiological processes and is involved in many diseases. Thus, real-time, rapid, and accurate monitoring of hypochlorite has important medical and physiological significance. Herein, a novel coumarin–pyridine derivative (CPD) probe was designed and synthesized, which exhibited fantastic advantages, such as a rapid response (within 10 s), naked eye recognition, large Stokes shift (185 nm), dual-channel detection, and high selectivity and sensitivity toward OCl (detection limit 0.012 μM, S/N = 3). Furthermore, the current CPD probe was successfully used to image OCl in the mitochondria of both A549 cells and zebrafish, which further demonstrated its suitability for practical applications in biological systems.

Graphical abstract: A mitochondria-targeted fluorescent probe based on coumarin–pyridine derivatives for hypochlorite imaging in living cells and zebrafish

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Publication details

The article was received on 08 Sep 2019, accepted on 14 Oct 2019 and first published on 17 Oct 2019


Article type: Paper
DOI: 10.1039/C9TB01948K
J. Mater. Chem. B, 2019,7, 7332-7337

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    A mitochondria-targeted fluorescent probe based on coumarin–pyridine derivatives for hypochlorite imaging in living cells and zebrafish

    X. Zhong, Q. Yang, Y. Chen, Y. Jiang, B. Wang and J. Shen, J. Mater. Chem. B, 2019, 7, 7332
    DOI: 10.1039/C9TB01948K

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