Jump to main content
Jump to site search


Self-quenching synthesis of coordination polymer pre-drug nanoparticles for selective photodynamic therapy

Author affiliations

Abstract

The design and preparation of a photoactive coordination polymer nanoplatform with tumor-related stimuli-activatability and biodegradability is highly desirable for achieving highly precise photodynamic therapy (PDT). Herein, novel “pre-photodynamic” nanoparticles (Fe-IBDP NPs) with a tumor microenvironment (TME)-activatable PDT and good biodegradability were synthesized by carrying out facile coordination assembly of an IBDP photosensitizer with an Fe3+ quenching agent. After being taken up by cancer cells, our “inactive” Fe-IBDP NPs were activated by the TME and as a result decomposed and released the photoactive carboxyl-functionalized diiodo-substituted BODIPY (IBDP) photosensitizer, which generated cytotoxic singlet oxygen (1O2) under light irradiation. By contrast, these NPs showed relatively low cytotoxicity in normal cells. This work also provided a feasible method for preparing the next generation of photoactive nanomedicines for use in precise phototherapy.

Graphical abstract: Self-quenching synthesis of coordination polymer pre-drug nanoparticles for selective photodynamic therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Sep 2019, accepted on 09 Nov 2019 and first published on 11 Nov 2019


Article type: Paper
DOI: 10.1039/C9TB01937E
J. Mater. Chem. B, 2019, Advance Article

  •   Request permissions

    Self-quenching synthesis of coordination polymer pre-drug nanoparticles for selective photodynamic therapy

    Y. Song, Y. Li, Y. Zhang, L. Wang and Z. Xie, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB01937E

Search articles by author

Spotlight

Advertisements