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Robust organic nanoparticles for noninvasive long-term fluorescence imaging

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Abstract

Fluorescence imaging is a non-invasive imaging technique, which facilitates the visualization of sub-cellular components in cells with high sensitivity and selectivity. Up to now, only indocyanine green (ICG) has been approved as a diagnostic reagent for intravenous application. But the intrinsic disadvantage of ICG has spurred more research attention to exploit new fluorescent materials in imaging fields. In the last decade, many materials, including inorganic and organic materials, have been developed for fluorescence imaging. There are some reviews about fluorescence bioimaging. In this review, we will summarize and highlight the reported organic nanoparticles for noninvasive long-term bioimaging. According to the emitting mechanism, fluorescent nanoparticles obtained from fluorophores with aggregation-caused quenching and aggregation-induced emission features are discussed respectively. Finally, we come up with some key issues and challenges in the future and clinical translation.

Graphical abstract: Robust organic nanoparticles for noninvasive long-term fluorescence imaging

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Publication details

The article was received on 04 Sep 2019, accepted on 11 Oct 2019 and first published on 18 Oct 2019


Article type: Review Article
DOI: 10.1039/C9TB01905G
J. Mater. Chem. B, 2019, Advance Article

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    Robust organic nanoparticles for noninvasive long-term fluorescence imaging

    Y. Guan, T. Sun, J. Ding and Z. Xie, J. Mater. Chem. B, 2019, Advance Article , DOI: 10.1039/C9TB01905G

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